02261-MOU: Improvement of Risk Assessments for Dermatomyositis Testing

Grant Status: Open

Grant Amount: $11,704
Dr. Leigh Anne Clark, PhD, Clemson University
April 1, 2016 - March 31, 2017
Sponsor(s): American Shetland Sheepdog Association
Breed(s): Shetland Sheepdog
Research Program Area: Dermatology and Allergic Disease

Abstract

Dermatomyositis (DMS) is an autoimmune disease of the skin and muscle that is diagnosed almost exclusively in Shetland sheepdogs and collies. The onset of clinical signs of DMS can range from just a few months to several years of age, making elimination of DMS nearly impossible. Dr. Clark and her team have conducted genomic studies and identified genetic sequences that are highly associated with DMS development. This work has led to a genetic test for risk alleles of three different genes. Availability of a genetic test will allow breeders to identify breeding pairs that will produce puppies having genotypic combinations associated with a low risk of disease development, as well as to gradually reduce the frequency of risk alleles in the population. In order to increase the utility of this test, Dr. Clark will generate genotypes for a random population (i.e., not selected for or against DMS) for calculation of risk assessments. There are 18 possible genotypic combinations between the three genes, and it is necessary to study a large population to ensure that each genotype is observed several times and that accurate risk assessments are available.

Funding for the research is provided through the efforts and generosity of the American Shetland Sheepdog Association. The AKC Canine Health Foundation supports the funding of this effort and will oversee administration of funds and scientific progress reports.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $40
  • $60
  • $100
  • $250
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2016 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software