Endocrinology Grants

The AKC Canine Health Foundation supports basic science discovery and clinical research into the treatment of diseases of the endocrine system through the Endocrinology Research Program Area. This program supports research into the genetic and epigenetic cause of disease; therapeutic applications of stem cells; novel imaging technologies with diagnostic and prognostic utility; biomarker development and the identification of potential therapeutics to treat endocrine disorders.

Active Grants:

 02659 Breed Specific Reference Ranges for Canine Thyroid Testing
 02488 Addison's Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders
 02428 Identifying the Disease-Defining Autoantibodies in Canine Addison's Disease

Previously Awarded Grants:

 02342-A Molecular Analysis of Giant Schnauzer-Type Congenital Hypothyroidism
 02366-A Individualization of Pharmacological Interventions in Diabetic Dogs
 02417-A Serum total histones in dogs with acute pancreatitis, their association with laboratory findings, markers of inflammation and outcome: a prospective longitudinal study
 02343-A Recognizing and Removing Lipemic Interferences for Accurate Laboratory Testing
 02298-MOU Using OFA Testing to Assess Progression of Canine Autoimmune Thyroiditis
 02138 Development of Accurate Diagnostic Tests for Canine Hypothyroidism
 2011 Identification of Novel Drugs to Halt the Metastasis of Tumors That Cause Cushing's Syndrome
 1602 Defining the Cause of Hyperadrenocorticism
 01684-A Improved Method for Early Diagnosis of Atypical Cushing's Disease
 01674-A Molecular Basis of Congenital Hypothyroidism with Goiter in Spanish Water Dogs
 372 Determination of Breed-Specific Reference Ranges for Assessing Thyroid Function in Several Breeds
 01233-A Examining Hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers Utilizing Whole Genome SNP Association
 610 Evaluation of Genetic Markers for Diabetes Mellitus in Samoyed and Australian Terrier Dogs
 01236-A Hypothyroidism and AutoImmune Susceptibility Genes in the Bearded Collie
 01235-A Genome Wide Association Mapping to Identify Genes Associated with Hypoadrenocorticism in the Bearded Collie
 01077-A Characterization of a P-Type ATPase, an Integral Membrane Protein in Dog Adipose Tissue: a Novel Target for Metabolic Diseases in Mammals
 00876-A Performing a whole genome screen on Rhodesian Ridgebacks with thyroglobulin antibody positive hypothyroid disease
 631 The Genome Wide Search for the Genetic Cause of Primary Hyperparathyroidism in the Keeshond
 00589A Identifying Genes Regulating Addison's Disease in the Portuguese Water Dog (PWD)
 00589B Identifying Genes Regulating Addison's Disease in the Portuguese Water Dog (PWD)
 00877-A Collecting a Second Cohort of Hypothyroid Dogs
 00844-A Effect of Phytoestrogens Enterolactone and Enterodiol on Steroidogenesis in Adrenal Cells: Investigating a Potential Therapy for Canine Hyperestrinism
 594 Effect of Melatonin on Adrenal Steroids in Dogs with Aberrant Adrenocortical Disease
 2434 Recombinant Thyrotropin (TSH): Standard for the Next Generation of Canine TSH Immunoassays with Improved Sensitivity
 225 Establishing a Genetic Linkage Between Addison's Disease and DNA Markers

The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

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