01914-A: Defining the Genes That Contribute to the Development of Soft Tissue Sarcomas

Grant Status: Closed

Grant Amount: $12,960
Dr. Kim Miranda Boerkamp, DVM, University of Utrecht
March 1, 2013 - May 31, 2014
Breed(s): Labrador Retriever
Research Program Area: Oncology

Abstract

Soft Tissue Sarcoma (STS) defines a group of tumors that originate in structural and connective tissue, and are responsible for 15% of all tumors that occur in dogs. STS are characterized by generalized infiltrative growth into soft tissue. This infiltrative growth and their relative resistance to chemotherapy and radiotherapy make these tumors very difficult to treat. Labrador retrievers are at greater risk for STS than other breeds. Dr. Boerkamp has identified two genomic regions associated with STS in Labrador Retrievers, and will continue her research by further defining the responsible mutations in these regions by large scale DNA sequence analysis. Dr. Boerkamp believes that once mutations that cause STS have been identified, a DNA test can be developed to assist breeders in reducing the incidence of the disease. In addition, she intends to compare European and American Labrador Retriever samples in order to determine whether genetic mutations are shared in different populations within the breed.

Publication(s)

None at this time.

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