00828-A: Investigation of genes identified by a canine-specific microarray may support a deficiency in cholesterol biosynthesis in the Havanese

Grant Status: Closed

Grant Amount: $12,910
Dr. Keith E. Murphy, PhD, Texas A&M University
September 1, 2006 - December 31, 2006
Sponsor(s): Bernese Mountain Dog Club of America, Flat-Coated Retriever Foundation, Golden Retriever Foundation
Breed(s): Havanese
Research Program Area: Prevention

Abstract

The Havanese is a toy breed in which a large number of dogs present, from birth, with a wide range of abnormalities. Bowed, shortened, or asymmetric legs occur with the highest frequency. Eye, liver, heart, testes, and dental abnormalities are also common in the breed. The organs that are affected in the Havanese are also affected in a group of cholesterol-related diseases in the human and mouse. We have analyzed a small group of dogs to determine whether these abnormalities are hereditary, rather than occurring spontaneously throughout the breed. Also, by studying gene expression � identifying genes that are turned on or off in different groups of dogs � a small number of genes that may provide information to help us better understand this disease were identified. We hypothesize that cholesterol plays a role in this disease and we would like to more closely examine a subset of nine genes to test our theory.

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