00329-A: Genetics of Post-Squalene Cholesterol Biosynthesis in the Havanese, Akita and Samoyed: Are Defects in this Pathway Responsible for an Array of Developmental Abnormalities- A Pilot Study

Grant Status: Closed

Grant Amount: $12,960
Keith E. Murphy, PhD; Texas A&M University
July 1, 2004 - June 30, 2005

Sponsor(s): American Boxer Charitable Foundation, Golden Retriever Foundation

Breed(s): Havanese, Samoyed, Akita
Research Program Area: Neurology
Donate to Support this Research Program Area

Abstract

This project is designed to eventually identify the causative gene(s) for post-squalene cholesterol biosynthesis. Research focused on cholesterol biosynthesis is increasingly directed towards understanding the genetics governing diseases related to this important sterol. Whereas most metabolic diseases are characterized largely by postnatal biochemical toxicities or deficiencies, disorders of cholesterol biosynthesis are notable for their severe effects on prenatal development.

Publication(s)

Starr, A. N., Famula, T. R., Markward, N. J., Baldwin, J. V., Fowler, K. D., Klumb, D. E., … Murphy, K. E. (2007). Hereditary Evaluation of Multiple Developmental Abnormalities in the Havanese Dog Breed. Journal of Heredity, 98(5), 510–517. https://doi.org/10.1093/jhered/esm049

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $50
  • $100
  • $250
  • $1000
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2018 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software