00329-A: Genetics of Post-Squalene Cholesterol Biosynthesis in the Havanese, Akita and Samoyed: Are Defects in this Pathway Responsible for an Array of Developmental Abnormalities- A Pilot Study

Grant Status: Closed

Grant Amount: $12,960
Dr. Keith E. Murphy, PhD, Texas A&M University
July 1, 2004 - June 30, 2005
Sponsor(s): American Boxer Charitable Foundation, Golden Retriever Foundation
Breed(s): Havanese, Samoyed, Akita
Research Program Area: Prevention

Abstract

This project is designed to eventually identify the causative gene(s) for post-squalene cholesterol biosynthesis. Research focused on cholesterol biosynthesis is increasingly directed towards understanding the genetics governing diseases related to this important sterol. Whereas most metabolic diseases are characterized largely by postnatal biochemical toxicities or deficiencies, disorders of cholesterol biosynthesis are notable for their severe effects on prenatal development.

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