00685-A: Standardization of Allergic Disease Serologic Testing with House Dust Mite Specific Canine lgE Monoclonal Antibodies

Grant Status: Closed

Grant Amount: $12,000
Bruce Hammerberg, DVM, PhD; North Carolina State University
September 1, 2005 - August 31, 2006

Sponsor(s): Bull Terrier Club of America

Breed(s): -All Dogs
Research Program Area: Immunology and Infectious Disease
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Allergic diseases affect all breeds of dog but manifest with greater frequencies in certain breeds due to as yet unknown genetic factors. This laboratory is committed to the discovery of the genetic factors associated with allergen disease pathogenesis; however, there is an immediate need for characterizing each allergic dog with regard to its particular allergen sensitivities in order to deliver effective treatment to individual dogs. In many clinical circumstances this characterization relies heavily on serological assays for allergen-specific IgE that are provided by commercial laboratories to veterinarians. Unfortunately, the validity of these services has been recently demonstrated to be highly inconsistent (DeBoer et al, 20th Proceeding of North American Veterinary Dermatology Forum, 2005, abstract). This proposed study will provide a mechanism for standardizing serological assays for allergen-specific IgE.


Orton, S. M., Arasu, P., & Hammerberg, B. (2007). A novel gene from Brugia sp. that encodes a cytotoxic fatty acid binding protein allergen recognized by canine monoclonal IgE and serum IgE from infected dogs. Journal of Parasitology, 93(6), 1378–1387. https://doi.org/10.1645/GE-1217.1

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