975: Characterization and Modulation of Canine Mast Cell Derived Eicosanoids

Grant Status: Closed

Grant Amount: $34,363
Dr. Cheryl A. London, DVM PhD, Ohio State University
April 1, 2008 - March 31, 2010
Sponsor(s): Old English Sheepdog Club of America, Staffordshire Terrier Club of America
Breed(s): -All Dogs
Research Program Area: Treatment

Project Summary

Dr. London's research team has been investigating the production of inflammatory mediators (also known as eicosanoids) by canine mast cells that contribute to a variety of diseases such as atopy and arthritis. The purpose of their work is to determine if currently available non-steroidal antiinflammatory drugs (NSAIDs) such as Rimadyl and Zubrin (among others) are capable of modifying their production. The use of NSAIDs would be an attractive alternative to the use of corticosteroids to modulate mast cell function. The preliminary data indicate that Zubrin is very effective at blocking the production of mast cell derived eicosanoids when mast cells are exposed to standard doses of drug. Therefore, results from these studies may provide a new strategy to modify the function of mast cells in several inflammatory disorders.

Publication(s)

Lin, T.-Y., London, C.A., 2010, Characterization and modulation of canine mast cell derived eicosanoids. Veterinary Immunology and Immunopathology 135, 118-127.

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