2290: Mapping Canine X Chromosome Linked Alopecia

Grant Status: Closed

Grant Amount: $14,415.7
Dr. Gary S. Johnson, DVM PhD; University of Missouri, Columbia
April 16, 2002 - March 31, 2003
Sponsor(s): American Pomeranian Club, Inc., Anonymous, Pomeranian Philanthropists
Breed(s): Pomeranian, Keeshond, Alaskan Malamute
Research Program Area: Prevention

Abstract

Many young Pomeranians develop a luxurious puppy for first hair coat which fails to shed and is not replaced by an adult coat. As the puppy coat ages it breaks off and falls out and can result in a dog that is hairless over much of its body. This disease is sometimes called black skin disease, coat funk or woolly coat. It also occurs in Keeshonden and Alaskan Malamutes. Although females can have the disease, it is much more common in males. This suggests, but does not prove, that the mutation responsible for the disease is on the X chromosome. We propose to determine if a DNA marker from the canine X chromosome associates with the disease. If so, this marker could then be used to distinguish genetically normal puppies from puppies that are likely to develop the disease. This marker could also identify female puppies that will not develop the disease but are likely to pass the disease on to the next generation.

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