Displaying results 31 - 36 of 36 items found.
31. Hypothyroidism and Autoimmune Susceptibility Genes in the Bearded Collie
(Web Page; Thu Aug 26 08:44:00 CDT 2021)
Description:
Background: Autoimmune disorders, for which hypothyroidism is one, have been cited by dog breeders as a concern. Reports suggest that higher inbreeding is correlated with autoimmune disease expression. A diagnosis of hypothyroidism often accompanies other immune mediated diseases and many breeds are afflicted with several autoimmune disorders. This evidence suggests different autoimmune diseases actually reflect a common set of susceptibility genes that express differentially depending upon additional genetic mutations carried by an individual dog. Objective: The researchers are extensively examining the entire canine genome utilizing state-of-the-art technologies to search for chromosomal regions associated with hypothyroidism. They will then explore the genetic relationship between hypothyroidism and another immune mediated disease present in the Bearded Collie population, Addison's disease. Common genomic regions associated with both diseases would suggest a single set of susceptibility genes underlying endocrine immune mediated disorders.
32. Study of PLE/PLN (Protein-losing Enteropathy/Nephropathy) in Soft-Coated Wheaten Terriers
(Web Page; Wed Jun 10 12:30:00 CDT 2020)
Description:
In 1997 the Soft-coated Wheaten Terrier (SCWT) Club of America helped us start an Open Registry which lists dogs affected with familial diseases common to this breed such as inflammatory bowel disease (IBD), protein-losing enteropathy (PLE), protein-losing nephropathy (PLN), combination PLE/PLN, Addison's disease (AD), and juvenile renal disease/renal dysplasia (JRD). The 2009 update lists almost 1000 affected dogs, with the vast majority affected with PLN, PLE, or PLE/PLN, in that order. These protein-losing diseases have had a devastating impact on the SCWT breed because: 1) there are no predictive tests, just annual screening tests, 2) there is no age limit, so dogs might be used for breeding before they show illness, and 3) the mode of inheritance is unknown and appears complex. The PennVet SCWT DNA Bank contains more than 500 blood or tissue samples from affected dogs as well as geriatric (14 years or older) non-affected Wheatens. Most affected samples are from confirmed PLE and/or PLN cases, with diagnosis documented by blood, urine, and histopathology test results. The proposed study will utilize SNP chip and genome-wide association analysis to identify chromosomal regions that are associated with these serious diseases. Further testing (fine-mapping) of regions of interest may then reveal specific mutations, deletions, or insertions, which could be used to identify carriers of disease-predisposing alleles. We also hope to learn more about the pathogenesis of these diseases (immune-dysregulation vs. structural/functional abnormalities) which may help Wheatens, other breeds of dogs, and humans with these diseases.
33. Refining the Genetic Mutations That Cause SLO in Bearded Collies
(Web Page; Mon Nov 22 08:57:00 CST 2021)
Description: Investigators have refined our knowledge of genetic mutations associated with immune system function that predict the development of symmetrical lupoid onychodystrophy (SLO) in the Bearded Collie.
34. Encouraging the Next Generation of Canine Health Researchers – A Success Story
(Web Page; Mon Dec 16 10:39:00 CST 2019)
Description: Read about the success of one AKC Canine Health Foundation Clinician-Scientist Fellowship alumnus - CHF-funded researcher and emergency/critical care veterinarian Dr. Steven Friedenberg.
(Web Page; Wed Nov 13 12:35:00 CST 2019)
Description: Highlights of AKC Canine Health Foundation-funded research findings presented at the 2019 National Parent Club Canine Health Conference
36. Major Histocompatibility Complex and Autoimmune Disease in Dogs
(Web Page; Wed Nov 10 20:16:00 CST 2010)
Description: The Major Histocompatibility Complex (MHC) can best be described as the factory floor of the immune system. An autoimmune disease is basically a condition where something “goes haywire” with the codes produced by the MHC, and the body basically turns on itself.
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