Understanding the Genetic Basis of Addison's Disease in Portuguese Water Dogs
The purpose of this study is to understand the genetic risk factors that lead to the development of Addison's Disease in Portuguese Water Dogs.
Affected: must be a typical Addisonian case with abnormal Na/K ratio and flat ACTH stimulation test at the time of diagnosis. Must be receiving cortisol replacement therapy (prednisone) and aldosterone replacement therapy (Percorten, Zycortal, or Florinef).
Unaffected: must be at least 10 years of age and apparently healthy. Owner must be willing to allow us to run a baseline cortisol test and/or an ACTH stimulation test to rule out Addison's disease.
Dog can reside anywhere, no specific restrictions; blood will be drawn at local veterinarians and be shipped to us via FedEx.
1. Participate in a brief survey about the dog's medical history
2. Be willing to bring the dog to a local veterinarian for a blood draw
3. Submit a pedigree, if available
4. Submit the dog's medical records for review (affected dogs only)
Name: Steven Friedenberg (PI) or Elizabeth Greif (graduate student)
Phone: 612-624-5148 (SF)
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.