Tolerability and Clinical Efficacy of Acetazolamide for Treatment of Hypochloremia in Canine Congestive Heart Failure

05/25/2022
Breed(s): -All Dogs
Sample Type: Clinical Study
Study Location: University of Florida
CHF-funded Grant: 03031

The University of Florida College of Veterinary Medicine is currently recruiting dogs with stable congestive heart failure (CHF) and hypochloremia (low blood chloride concentrations) for a clinical trial evaluating the effect of adding acetazolamide to standard-of-care CHF medications on blood chloride levels.

Participation Requirements:

Inclusion Criteria:  Dogs that weigh more than 4.4 lbs, have stable CHF (not requiring hospitalization), have underlying mitral valve disease and hypochloremia can be considered for enrollment.  The dogs must be treated with standard-of-care CHF medications and be willing to eat a diet specifically formulated for heart disease for the study duration (3 months).

Exclusion Criteria: Dogs with normal blood chloride concentrations, advanced kidney disease (serum creatinine >2.5 mg/dl), weight

Owner's Responsibilities:

This is a randomized, placebo-controlled study where dogs will receive either treatment with acetazolamide or placebo (suspension without medication in it) twice daily for 2 months.  Four visits to UF Cardiology are required.  Tests that will be done at these visits include bloodwork, urinalysis, chest xrays and an echocardiogram.

More Information

 

Contact Information:

Name: Dr. Adin
Phone: 352 392 2235

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