No Benefit to Using Fresh RBCs in Dogs with Existing Hemolysis


CHF Grant 1988: Identification of a Safe Storage Time for Canine Blood Used in the Treatment of Anemia

Callan, M. B., Thawley, V. J., Marryott, K. A., Shabro, A., Fernando, S., Kahn, S., Hudson, K. E., & Hod, E. A. (2021). Hemolytic anemia blunts the cytokine response to transfusion of older red blood cells in mice and dogs. Transfusion.

What can we learn?
Investigators conducted a prospective, randomized, blinded trial of 38 client-owned dogs with primary autoimmune hemolytic anemia (AIHA) and two dogs with immune-mediated thrombocytopenia (ITP) to assess whether transfusion of older red blood cells (RBCs) negatively impacts survival. While markers of hemolysis did increase following transfusion with older RBCs (stored > 21 days), there were no differences in morbidity or mortality between dogs randomized to receive fresh or old RBCs.

There is no apparent benefit to using fresh RBC transfusions in dogs with underlying, baseline hemolysis.

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