Exploring Biomarkers for Immune Thrombocytopenia

CHF Grant 02536-MOU: Immunoprofiling to Combat Canine Immune Thrombocytopenia

Publication:
Brooks MB, Goggs R, Frye AH, et al. A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs. J Vet Intern Med. 2024;1‐13. https://doi.org/10.1111/jvim.16985

What can we learn?
Investigators completed a prospective, multi-institution cohort study to identify clinicopathologic features that differentiate primary from secondary immune thrombocytopenia (ITP). While no biomarkers could definitively differentiate the two forms of this disease, they found that lower platelet counts, D dimer concentrations, and platelet membrane protein expression were more common in primary ITP. Additionally, low hematocrit and high BUN were associated with non-survival.

Conclusion:
Clinicopathologic findings at admission can help differentiate primary from secondary ITP in dogs and identify the most severe cases of primary ITP.