02363-A: Platelet Function in Dogs with Chronic Liver Disease

Grant Status: Open

Grant Amount: $14,904
Dr. David L. Panciera, DVM, Virginia-Maryland Regional College of Veterinary Medicine
June 1, 2017 - May 31, 2018
Breed(s): -All Dogs, Labrador Retriever
Research Program Area: Hepatic Disease

Abstract

Chronic liver disease is common among adult dogs with numerous breeds being predisposed. Liver biopsy is usually required to identify the underlying cause of liver disease in these patients, and is often recommended to monitor response to treatment. Because dogs with liver disease have abnormal clotting activity, bleeding is a substantial risk of biopsy. Routine screening for clotting abnormalities in dogs with liver disease is accomplished using blood tests including prothrombin time, partial thromboplastin time, and platelet count. Unfortunately, these routine tests do not necessarily correlate with excessive biopsy-induced bleeding, which makes predicting and preventing hemorrhage during liver biopsy difficult. Humans with liver disease have abnormal platelet function that contributes to abnormal coagulation. Because standard diagnostics do not assess platelet function, we propose to evaluate platelet function in dogs with chronic liver disease. The investigators will determine if dogs with chronic liver disease have platelet dysfunction and if there is a correlation between platelet function and bleeding after liver biopsy. to the research team will use two methods to evaluate platelet function in canine patients with chronic liver disease undergoing ultrasound guided liver biopsies to determine if there is a relationship between platelet function and hemorrhage after biopsy.

Publication(s)

None at this time.

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