2316: Genetic Risk Factors for Canine T zone Lymphoma

Grant Status: Open

Grant Amount: $52,894
Dr. Anne A. Avery, DVM, PhD, Colorado State University
January 1, 2017 - December 31, 2017
Breed(s): -All Dogs, Golden Retriever
Research Program Area: Oncology - Lymphoma

Abstract

The Golden Retriever is a breed that develops a variety of cancers at a high frequency. One type of cancer, T zone lymphoma, is so common in this breed that 40% of all cases are seen in Golden Retrievers. This observation suggests a clear genetic predisposition. The investigators have completed an environmental risk factor study and the first phase of a genetic risk factor study to better understand the causes of this disease. Two key findings from this work are, 1) The same genetic region associated with risk for mast cell tumors was identified as conferring risk for T zone lymphoma, and 2) The presence of hypothyroidism was protective for T zone lymphoma, and genes associated with thyroid function are also found in the risk regions. The goal of this study is to complete the genetic risk factor study by identifying specific genetic mutations associated with the disease. This research will improve understanding of the mechanisms that lead to T zone lymphoma as well as mast cell tumors in dogs.

Publication(s)

None at this time.

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