02107: Landmark Clinical Trial to Establish the Evidence-Based Use of Regenerative Medicine to Treat Tendon Injury in Dogs

Grant Amount: $254,509

Jennifer G. Barrett, DVM, PhD; Virginia-Maryland Regional College of Veterinary Medicine

December 1, 2019 - November 30, 2022

Sponsor(s): American Cavalier King Charles Spaniel Club Charitable Trust, American Chesapeake Club Charitable Trust, American German Shepherd Dog Charitable Foundation, Inc., American Field Pointer Association, Collie Health Foundation, English Setter Association of America, Inc., Golden Retriever Foundation, Gordon Setter Club of America, Inc., Irish Setter Club of America Foundation, Kuvasz Club of America, Labrador Retriever Club, Inc., National Redbone Coonhound Association, Poodle Club of America Foundation, Inc., Portuguese Water Dog Foundation, Retriever News - Entry Express, Siberian Husky Club of America, Inc.

Breed(s): -All Dogs

Research Program Area: Musculoskeletal Conditions and Disease

Abstract

This study will evaluate the effectiveness of Platelet-Rich Plasma (PRP) and stem cells in the treatment of the most common sporting injury in dogs: supraspinatus tendinopathy (similar to the rotator cuff injury in humans).  Tendon injuries in dogs often progress undiagnosed and result in chronic lameness and pain.  Ultimately, unassisted tendon healing results in scar formation and reduced function of the joint and surrounding muscle tissue.  PRP and stem cell therapies aim to accelerate and promote healing through tissue regeneration and reduced scarring.  The investigators will conduct a randomized, placebo-controlled clinical trial evaluating the effectiveness of PRP, adipose-derived, cultured stem cells (ASC) and commonly used stromal vascular fraction (SVF) cells to directly compare efficacy of intratendinous injection of ASC versus SVF, both of which are currently commercially available despite having limited scientific evidence of efficacy.  The investigators hope to identify an effective treatment to supraspinatus tendon injury.

Grant Period: 7/1/2014-6/30/2018; 12/1/2019-11/30/2022

Publication(s)

None at this time.