01345-A: Circulating Isoforms of B-type Natriuretic Peptide and the Pathogenesis of Canine Heart Failure
Grant Status: Closed
AbstractBackground: Congestive heart failure is a common cause of morbidity and mortality in many dog breeds. The physiological changes responsible for the debilitating symptoms caused by sodium and fluid buildup are poorly understood. This has hampered the development of appropriate treatments and management of this disease. One important factor responsible for the progression of the symptoms of canine congestive heart failure may be that such dogs develop an apparent lack of response to a major rescue hormone that is normally produced by cardiac cells to prevent the symptoms of heart failure. The hormone, B-type natriuretic peptide (BNP), is produced in large amounts, but appears ineffective in alleviating the symptoms of heart failure. Studies in non-canine species suggest that the cause of this may be production of inactive forms of BNP. Objective: The goal of this project is to determine whether circulating forms of inactive BNP occur in dogs with heart failure and therefore play a potential role in the occurrence of heart failure symptoms. The results of this study will be used to direct further studies into the diagnosis and management of this debilitating and common canine disease.
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