01175-A: Pilot Investigation of the Causes of Hemangiosarcoma in Clumber Spaniels

Grant Status: Closed

Grant Amount: $11,988
Dr. Nicholas S. Duesbery, PhD, Van Andel Research Institute
June 1, 2008 - May 31, 2009
Breed(s): Clumber Spaniel
Research Program Area: Prevention

Project Summary

Hemangiosarcomas (HSA) are soft-tissue tumors that arise from cells that line the inside of blood vessels. Although rare in humans, these tumors are relatively common in dogs, particularly in older (8 yrs and older), large breeds such as German Shepherds, Golden Retrievers, Flat-Coated Retrievers, Australian Shepherds, and Clumber Spaniels. The prevalence of this disease in certain breeds of dog suggests it is associated with an underlying genetic component. Identification of HSA-associated genes can lead to the development of prognostic tests that may be used to improve breeding strategies as well as novel therapies. With the support of the CHF a pilot study was initiated to study the causes of hemangiosarcoma in Clumber Spaniels. This study successfully achieved the goal to map out chromosomal regions that are associated with hemangiosarcoma. The preliminary data obtained from this project suggest that two recessive chromosomal loci are associated with development of hemangiosarcoma in Clumber Spaniels. The study also successfully analyzed patterns of gene activation in tumor samples and identified specific biochemical pathways that are activate in hemangiosarcoma. The pilot study was successful in building the program to continue to identify the causes of hemangiosarcoma in Clumber Spaniels.

Publication(s)

As of 9/22/09, no publications.

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