00988-A: Prevalence and Genetic Implications of Atrial Septal Defects in the Standard Poodle
Grant Status: Closed
AbstractStandard Poodles were recently reported to have an increased risk of being born with a specific heart malformation. The heart malformation consists of a hole between two chambers, the two atria. The malformation can result in signs of heart failure such as a cough or breathing difficulty, can shorten the patient's life, and can be passed on to puppies. The defect can sometimes be repaired but the techniques for repair are not routinely available. The defect is inherited but the pattern of inheritance has yet to be determined. This study will evaluate a large number of Standard Poodles to determine how many are affected and identify the pattern of inheritance so recommendations can be made to breeders. In addition, we hope to identify the genetic abnormality responsible for the defect so we can develop a blood test to evaluate whether or not Standard Poodles are affected with this defect in the future, particularly before they are used in breeding programs. We will also make recommendations regarding the need for repair to the owners of the dogs that are found to be affected.
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