00878-A: MicroRNA Expression in the Domestic Dog and Its Role in Canine Cancer
Grant Status: Closed
Abstract
A new group of genes, termed microRNAs, have been discovered to be associated with various cancers in the human. These genes are also found in dogs and have the exact same sequence as the human counterparts. Due to the great similarity between the human and dog, we hypothesize that these genes may also play a role in canine cancer. Our lab has used new technologies to isolate and quantify the products of these cancer related genes in one unaffected dog. We will use this established protocol to develop a baseline of normal expression in the dog, and then compare the baseline values to the gene expression levels in two cancerous cell lines. This may identify new genes that play a role in the initiation or progression of the specific cancers affecting the two cell lines. The ultimate goal is to use these methods to develop a diagnostic resource based on the expression profiles for every type of canine cancer.
Publication(s)
Related Grants
- 00978-A: Isolation of the Canine Telomerase Reverse Transcriptase (TERT) Subunit and Generation of Dominant-Negative Mutants for Telomerase Inhibition
- 00888-A: Generation of Canine Single Chain Fragment Variable Antibody Libraries for the Identification and Targeting of Tumor-Associated Antigens in the Dog
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
