00875-A: Analysis of Degenerative Myelopathy in the German Shepherd Dog Using the SNP Array
Grant Status: Closed
AbstractDegenerative myelopathy (DM) is a progressive, neurodegenerative disorder that is common in the large breed dogs, particularly the GSD. Onset of DM usually occurs in dogs 5 to 14 years old. Affected dogs will begin to drag their legs and exhibit other signs of weakness in the hind limbs. Currently, there is no defined diagnostic procedure or treatment regimen for DM. Most affected dogs are euthanized within one year of diagnosis. The cause of DM is unknown and very few studies have been conducted to understand the genetics underlying the disease. We propose herein to use the canine SNP array to evaluate differences between affected and unaffected GSDs in an effort to identify regions of the genome that may harbor genes involved in the disease.
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