00875-A: Analysis of Degenerative Myelopathy in the German Shepherd Dog Using the SNP Array

Grant Status: Closed

Grant Amount: $12,833
Dr. Leigh Anne Clark, PhD, Texas A&M University
February 1, 2007 - July 31, 2008
Sponsor(s): American Belgian Tervuren Club, Inc., Collie Health Foundation, Pyrenean Shepherd Club of America, Welsh Springer Spaniel Club of America
Breed(s): German Shepherd Dog
Research Program Area: Prevention

Abstract

Degenerative myelopathy (DM) is a progressive, neurodegenerative disorder that is common in the large breed dogs, particularly the GSD. Onset of DM usually occurs in dogs 5 to 14 years old. Affected dogs will begin to drag their legs and exhibit other signs of weakness in the hind limbs. Currently, there is no defined diagnostic procedure or treatment regimen for DM. Most affected dogs are euthanized within one year of diagnosis. The cause of DM is unknown and very few studies have been conducted to understand the genetics underlying the disease. We propose herein to use the canine SNP array to evaluate differences between affected and unaffected GSDs in an effort to identify regions of the genome that may harbor genes involved in the disease.

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