00809-A: Rel Transformation of Canine Lymphoid Cells: Towards the Development of Relevant Canine Lymphoma Cell Lines
Grant Status: Closed
AbstractIn this study we aim to use retroviral Rel expression plasmids to infect lymphocytes isolated from normal dogs and neoplastic lymphoblasts isolated from dogs with high-grade B cell lymphoma and document appropriate Rel and/or Bcl-2 protein expression. These experiments will provide proof of principle that Rel expression plasmids can infect and replicate in canine lymphoid cells and support our long-term goal of establishing pertinent canine lymphoma cell lines.
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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.