00809-A: Rel Transformation of Canine Lymphoid Cells: Towards the Development of Relevant Canine Lymphoma Cell Lines

Grant Status: Closed

Grant Amount: $10,800
Dr. Steven E. Suter, VMD PhD, North Carolina State University
July 1, 2006 - June 30, 2007
Breed(s): -All Dogs
Research Program Area: Treatment

Abstract

In this study we aim to use retroviral Rel expression plasmids to infect lymphocytes isolated from normal dogs and neoplastic lymphoblasts isolated from dogs with high-grade B cell lymphoma and document appropriate Rel and/or Bcl-2 protein expression. These experiments will provide proof of principle that Rel expression plasmids can infect and replicate in canine lymphoid cells and support our long-term goal of establishing pertinent canine lymphoma cell lines.

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