789: Identification of Candidate Genes Causative for Dilated Cardiomyopathy in the Dog

Grant Status: Closed

Grant Amount: $111,527
Dr. Keith E. Murphy, PhD, Texas A&M University
April 1, 2007 - September 30, 2009
Sponsor(s): Great Dane Club of America, Great Dane Club of America Charitable Trust
Breed(s): Great Dane
Research Program Area: Prevention

Project Summary

The initial goal of this project was to perform whole-genome screening in Great Danes for Dilated Cardiomyopathy using microsatelite markers (MSS-2 marker set.) A complex segregation analysis was performed to determine the inheritance mechanism. The results suggested that DCM is not likely inherited by a simple Mendelian fashion and is a complex disease most likely dictated by multiple genes, environmental factors, and behavioral factors. This emphasizes the difficulty in indentifying the genetic association to DCM. The microsatellite genetic screen results identified eight markers had a positive LOD score. But upon investigation, the researcher selected to use the new SNP technologies now available to perform genome wide association study. The SNP array found DCM associations in two chromosomes. The researchers are assessing genes on the aforementioned two chromosomes in order to catalog and determine if any are solid candidate genes. In addition, available Great Dane samples will be added in order to expand our data set for GWAS analysis. This continuation of the project is being done and no further support will be requested from CHF.

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