00717-A: Determination of White Spotting Locus in Dogs

Grant Status: Closed

Grant Amount: $12,960
Dr. Max F. Rothschild, PhD, Iowa State University
March 1, 2006 - February 28, 2007
Breed(s): Newfoundland, French Bulldog, Schipperke
Research Program Area: Prevention

Abstract

The advent of modern genomics has now made it possible to determine underlying gene effects on traits of major importance in the dog. Unlike many other domesticated species, in the dog the cause or causes of white spotting are not known. White spotting is of interest because extreme white spotting has been linked to health disorders including blindness and deafness in several breeds. Using some unique pedigrees selected to demonstrate simple inheritance of white spotting we plan to use two common approaches to find the gene or genes responsible. We will employ a limited genome scan and directed analyses of a number of candidate genes known to be associated with spotting in other mammalian species in specific canine pedigrees. Results of this effort will either identify specific genes and chromosomal regions or exclude them from further study. Results will be published and made available to all dog breeds.

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