00702-A: Serotonin and Transforming Growth Factor-B Signaling in Canine Mitral Valve Disease
Grant Status: Closed
AbstractVery little is known about the molecular mechanisms involved in degenerative mitral valve disease (DMVD) in dogs. Increased serotonin and transforming growth factor-� (TGF-�) signaling causes valvular disease in humans and experimental animal models. The pathologic characteristics of serotonin-TGF-�-mediated valve disease is very similar to DMVD. Previous research by the PI has shown significant upregulation of serotonin receptors and TGF-� signaling molecules in mitral valve tissue from affected dogs. We propose investigating the role of the serotonin-TGF-� pathway in mitral valves from dogs with severe DMVD. The findings of this study will advance our understanding of the pathophysiology of DMVD and may lead to blood tests that detect abnormal serotonin signaling as well as new pharmacologic interventions to blunt activity of this harmful pathway.
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