00687-A: Fluorescence-Activated Cell Sorting of Canine Pituitary Corticotroph Cells for Subsequent Microarray Analysis

Grant Status: Closed

Grant Amount: $8,000
Dr. Bjorn P. Meij, DVM PhD, University of Utrecht
October 1, 2005 - March 31, 2006
Breed(s): -All Dogs
Research Program Area: Treatment

Abstract

Canine pituitary-dependent hyperadrenocorticism (PDH), or Cushing's disease, is a severe and frequent endocrine disease in middle-aged to elderly dogs. Small breeds are over-represented and some breeds are at a higher risk of developing the disease than others. PDH is caused by an ACTH-producing pituitary adenoma with unknown pathogenesis. At the Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine of the University of Utrecht there is a long term commitment to study pituitary adenomas and it is the single veterinary institution where transsphenoidal hypophysectomies are performed as routine treatment for canine PDH. This study will lead to targeted studies with large scale genome, cDNA, and protein arrays to elucidate the pathogenesis in dogs.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $50
  • $100
  • $250
  • $1000
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2016 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software