00571-A: Identification of Canine Microsatellites Associated with Genes Known to Cause Progressive Retinal Atrophy in Dogs and Retinitis Pigmentosa in Humans

Grant Status: Closed

Grant Amount: $12,960
Dr. Cathryn S Mellersh, Ph.D., Animal Health Trust
April 1, 2005 - June 30, 2005
Breed(s): Tibetan Spaniel, Golden Retriever
Research Program Area: Prevention

Abstract

Progress retinal atrophy (PRA) is an encompassing name for a group of canine inherited retinal degenerations that affect many different breeds of dog and is the phenotypic equivalent of human retinitis pigmentosa (RP). There is no treatment to cure P/RA and no treatment to stop its progression; dogs affected with PRA invariably go blind. Mutations causing PRA in a small number of breeds have been identified and it is now firmly established that PRAs in different breeds are often caused by mutations in different genes. We have previously identified microsatellites in nine genes known to cause PRA in dogs or RP in humans.

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