00567-A: Mapping the Genetic Lesion of Primary Lens Luxation in Lancashire Heelers, Miniature Bull Terriers and Other Terrier Breeds

Grant Status: Closed

Grant Amount: $9,586
Dr. David Sargan,, University of Cambridge
January 1, 2005 - December 31, 2005
Breed(s): Miniature Bull Terrier
Research Program Area: Prevention

Abstract

Primary Lens Luxations (PLLs) are painful and blinding ocular conditions recessively inherited in a range of terrier and other dog breeds. In this project, we will 1) use linkage disequilibrium mapping to establish the genetic location of the mutation causing PLL in Miniature Bull Terriers and Lancashire Heelers; 2) begin cloning candidate genes for causation of PLL from this region; 3) screen these genes for mutations in PLL dogs of various terrier breeds. Ultimately, our aim is to produce one or more DNA-based tests for PLL in terrier breeds.

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