440: A Molecular Evaluation of Two Forms of Canine Cardiomyopathy

Grant Status: Closed

Grant Amount: $77,755
Dr. Kathryn M Meurs, DVM PhD, Washington State University
January 1, 2006 - December 31, 2006
Breed(s): Doberman Pinscher, Boxer
Research Program Area: Prevention

Abstract

Cardiomyopathy is the second most common heart disease diagnosed in the dog. The two most common forms of canine cardiomyopathy are dilated cardiomyopathy (DCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC). Both are adult onset, familial diseases that frequently progress to sudden death and/or heart failure. We hypothesize that these diseases can each be mapped to a separate, location on a canine chromosome. The objective of this study is to perform a genome wide scan using DNA samples from families of Doberman Pinschers with DCM and Boxers with ARVC. Canine genetic markers will be evaluated to identify a chromosomal location linked to each of these diseases. The identification of a chromosomal location linked to the disease will allow additional evaluation of this region for a gene responsible for the disease and may be useful for the identification of at risk dogs even before the causative gene is identified.

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