00360-A: Genome Expression Profiling: Canine Cardiomyopathy and Degenerative Mitral Valve Disease

Grant Status: Closed

Grant Amount: $10,315
Dr. Mark A. Oyama, DVM, University of Illinois
October 1, 2004 - September 30, 2005
Breed(s): Doberman Pinscher, Boxer
Research Program Area: Prevention

Abstract

Canine cardiomyopathy and degenerative valve disease have proven to be highly complex conditions, with multiple potential etiologies, elaborate and interrelated pathophysiologic mechanisms, and a diverse phenotypic expression. The analysis of such complex systems would benefit from a global assessment of gene expression. Because gene expression is the primary regulator of cell function, expression profiling in diseased subjects could provide valuable information about the response of the cell to injury, activity of physiologic pathways, and possible etiologies. Expression profiling may also enable the identification of diagnostic or prognostic markers, thereby improving the clinical management of disease. To this end, genomic microarrays represent an emerging technology that can assess the activity to profile the genome on a global scale. Using a newly developed canine gene microarray, we seek to profile genome expression in ventricular tissue of dogs with cardiomyopathy in mitral valve tissue in dogs with age-related mitral disease, and to compare the genomic expression in these populations with controls from an age and breed matched population. Genomic profiling will provide a molecular portrait of cardiomyopathy and degenerative valve disease.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $40
  • $60
  • $100
  • $250
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2015 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software