00325-A: A Candidate Gene Approach for Skeletal Dysplasia in the Newfoundland, Chesapeake Bay Retriever and Nova Scotia Duck Tolling Retriever

Grant Status: Closed

Grant Amount: $11,750
Dr. Danika L Bannasch, DVM PhD, University of California, Davis
April 1, 2004 - March 31, 2005
Breed(s): Newfoundland, Chesapeake Bay Retriever, Nova Scotia Duck Tolling Retriever
Research Program Area: Prevention

Abstract

Canine skeletal dysplasias are a poorly classified group of heritable defects leading to disproportionate dwarfism and cartilage abnormalities. The purpose of this study is to examine the type X collagen gene (COL10A1) for defects that could lead to skeletal dysplasia in the Newfoundland, Chesapeake Bay Retriever and Nova Scotia Duck Tolling Retriever. These breeds suffer from an inherited defect of endochondral ossification with phenotypic similarities to human Schmid type Metaphyseal Dysplasia. Several mutations in the COL10A1 gene have been found that lead to the human disease, as well as metaphyseal dysplasia in domestic pigs. The disbursement of the Newfoundland and Chesapeake Disease trait throughout several lines suggests that the mutation may have been introduced into the Chesapeake breed during early matings with Newfoundlands. The COL10A1 gene will be investigated as a candidate for the skeletal dysplasia that is segregated through these three breeds.

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