00324-A: Molecular Genetic Characterization of Canine Non-Syndromic Deafness

Grant Status: Closed

Grant Amount: $12,960
Dr. Paula S. Henthorn, PhD; University of Pennsylvania
April 1, 2004 - March 31, 2005
Breed(s): Pointer
Research Program Area: Prevention


We propose to characterize a form of canine inherited deafness. This deafness is classified as non-syndromic, neuroepithelial, and is inherited as an autosomal recessive trait in a large pedigree of dogs originally from Pointers. A genetic approach for the identification of the gene responsible for this canine disorder is now possible because of the recent availability of canine linkage and radiation hybrid maps and other genetic resources of sufficient resolution for comparative positional-candidate cloning of disease genes.

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