02610-A: The Role of Motilin Signaling in Canine Osteoarthritis

Grant Status: Open

Grant Amount: $15,000
Li Zeng, PhD; Tufts University
March 1, 2019 - February 29, 2020
Breed(s): -All Dogs
Research Program Area: Musculoskeletal Conditions and Disease

Abstract

Osteoarthritis is a devastating disease characterized by joint pain and immobility and while it is highly prevalent in dogs, there is no optimal treatment for this disease. The goal of this study is to design strategies to prevent osteoarthritis progression and improve the quality of life for dogs. A central feature for osteoarthritis is the destruction of joint cartilage, a tissue that normally serves as a cushion between bones. Without this cushion, there is increased friction at the joint, causing mechanical stress and accelerating joint degeneration. One treatment strategy is to combat inflammation, because inflammation results in joint cartilage loss and is a key component in the pathogenesis of osteoarthritis. In preliminary studies, the investigators found that the hormone motilin has an anti-inflammatory activity that has not been previously reported. Their hypothesis is that motilin protects the canine joint against inflammation and improves the health of the cartilage in osteoarthritis. Outcomes of this research may benefit both dogs and humans suffering from osteoarthritis.

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