00205-A: Relationship of Clinical Stage and Ki-67 Expression to Recurrence Following Radiotherapy of Canine Intranasal Neoplasia

Grant Status: Closed

Grant Amount: $7,471.34
Dr. WM Adams, DVM, University of Wisconsin, Madison
April 1, 2004 - March 31, 2005
Sponsor(s): American Boxer Charitable Foundation, Berner Lovers, Bernese Mountain Dog Club of America, CanCog Technologies, Inc., Collie Health Foundation, Flat-Coated Retriever Foundation, Golden Retriever Foundation
Breed(s): -All Dogs
Research Program Area: Treatment

Abstract

This study will test the usefulness of canine intranasal tumor staging systems, plus a promising biologic marker tested on a large series of dogs treated similarly for intranasal neoplasia. The intent is to identify a system that could become the benchmark of initial evaluation for this tumor type. Biologic behavior of intranasal neoplasia (INN) in a serious of affected dogs, all treated in the same manner with radiotherapy, has been recorded in the University of Wisconsin Veterinary Medical Teaching Hospital (UMVMTH) computerized data base system. Biologic behavior findings will be compared to pretreatment assessment of severity of the disease as determined by application of 3 published and one new proposed staging systems, based on computed tomography (CT) findings. Further, biologic behaviors of INN in this series of dogs will be compared to expression of the biologic marker Ki-67, found in pretreatment biopsy samples.

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