2620: Determination of the Clinical Phenotype and Inherited Nature of Familial Subvalvular Aortic Stenosis in the Rottweiler

Grant Status: Closed

Grant Amount: $15,438.37
Dr. Kathryn M Meurs, DVM PhD, Ohio State University
October 1, 2003 - September 30, 2005
Sponsor(s): American Boxer Charitable Foundation, American Miniature Schnauzer Club, Inc., American Spaniel Club Foundation, Bull Terrier Welfare Foundation, Bulldog Club of America Charitable Health Fund, Inc., Collie Health Foundation, Flat-Coated Retriever Foundation, Golden Retriever Foundation, Great Dane Club of America, Rhodesian Ridgeback Club of the United States, Scottish Terrier Club of America
Breed(s): Rottweiler
Research Program Area: Treatment

Abstract

Subvalvular aortic stenosis (SAS) is a congenital heart disease characterized by a fibrous ridge located below the aortic valve. Affected dogs are at risk of developing heart valve infections, congestive heart failure or sudden death. This trend has been reported with increasing frequency in the Rottweiler. The defect has been shown to be inherited in the Newfoundland breed, however the inherited nature of the disease in other breeds of dogs, including the Rottweiler, is unknown. The objectives of this study are to define the clinical presentation of SAS in the Rottweiler, compile pedigrees with reference to defined clinical cardiovascular status and evaluate for specific modes of inheritance, and accumulate a databank of clinical information, pedigrees and DNA from Rottweilers affected with SAS and all surviving familiy members. This study will help define both the clinical attributes and inherited nature of the disease. Information obtained in this study will provide the background for developing both screening and treatment programs and provide the initial materials for molecular studies to be performed in the future.

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