2267: Linkage Analysis of Familial Subvalvular Aortic Stenosis in the Newfoundland Dog

Grant Status: Closed

Grant Amount: $63,095
Kathryn M Meurs, DVM, PhD; Ohio State University
November 8, 2001 - December 31, 2003

Sponsor(s): Newfoundland Club of America Charitable Trust, NewPenDel Newfoundland Club

Breed(s): Newfoundland
Research Program Area: Cardiology
Donate to Support this Research Program Area


Subvalvular Aortic Stenosis (SAS) is a familial congenital heart disease characterized by a fibrous ridge located below the aortic valve. Affected dogs are at risk of developing an infection on the aortic valve, congestive heart failure or sudden death. This is a familial defect in the Newfoundland dog; therefore affected dogs should not be bred. However, mildly affected dogs can be difficult to diagnose without Doppler echocardiography, an expensive test with limited availability. Therefore, there is significant interest in developing a genetic test to screen for SAS. The study proposed builds on a previous study funded by the AKC/CHF to recruit and screen families of Newfoundland dogs with SAS. Dogs have been classified as affected, unaffected but related to affected, or unaffected by Doppler echocardiography. Pedigrees and DNA samples have been collected on several small families. Additional recruitment of grandparents and siblings will complete these families. Genetic analysis will be performed using canine markers and DNA samples from these families. Genetic markers will be evaluated to determine if they are associated with SAS in the Newfoundland. The identification of a genetic marker linked to SAS will be the first step in the development of a DNA screening test.


None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $50
  • $100
  • $250
  • $1000
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2018 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software