2230: Continued DNA Studies in Cataracts in the Bichon Frise

Grant Status: Closed

Grant Amount: $12,300
Dr. Kirk Gelatt, VMD, University of Florida
October 1, 2001 - December 31, 2002
Sponsor(s): Bichon Frise Club of America, Inc.
Breed(s): Bichon Frise
Research Program Area: Prevention

Abstract

Cataracts affect more breeds of dog than any other ophthalmic disease. Cataracts are first reported in the Bichon Frise breed in 1996. During this two-year study supported by the AKC Canine Health Foundation, we examined nearly 300 Bichon Frises. These dogs were normal, carrier or cataractous animals and about 60 percent provided blood samples for DNA analysis. In this study and additional 30 to 50 dog samples will be collected and analyzed to expand our Homozygosity mapping and basic linkage analyses. Very recently an adult onset cataract has been reported in man associated with chromosome 3p21. Four markers for this syntenic region in the dog (chromosome CFA20) have been tested in the Bichon Frise, and two markers on this chromosome demonstrate Homozygosity or partial Homozygosity (an association with the cataract). Using a computer linkage analysis, the pedigrees are to be studied for general linkage. Using silver stained polyacrylamide genes we will genotype several tetranucleotide markers for homozygosity mapping. Our goal remains to identify the Bichon Frise cataract gene.

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