2226: Characterizing the Inheritance of Addison's Disease and Linked DNA Markers
Grant Status: Closed
AbstractAddison�s disease is a late onset disorder caused by the deterioration of the adrenal gland. Addison�s occurs in the domestic dog at approximately 0.1 percent, with some breeds showing a greater prevalence. Notably, the Bearded Collie, the West Highland White Terrier, the Standard Poodle, the Portuguese Water Dog, and the Leonberger are considered to have unacceptable rates of Addison�s disease. Breeders have noted a familial tendency of Addison�s disease suggesting a genetic basis to the disorder. Our laboratory has determined that Addison�s is highly heritable in Bearded Collies. Further, although Addison�s is not fully governed by a single locus in the Bearded Collie, it does appear to be regulated by a single gene of large effect. The specific objectives of this study are to develop a genetic marker associated with an Addison�s locus in the Bearded Collie; such a genetic marker will provide a useful tool to aid breeders in making health-based breeding decisions. The second objective is to determine if Addison�s disease in the Standard Poodle, West Highland White Terrier, Portuguese Water Dog and Leonberger also has a genetic basis and if so, whether there is a common genetic defect across all these breeds.
Publication(s)- Oberbauer, A.M., Bell, J.S., Belanger, J.M., Famula, T.R., 2006, Genetic evaluation of Addison's disease in the Portuguese Water Dog. BMC Veterinary Research 2, 15. - Famula, T.R., Belanger, J.M., Oberbauer, A.M., 2003, Heritability and complex s
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