0001729: Canine Epilepsy: Determining the Mode of Inheritance, Mapping the Genes, and Developing Linkage Test
Grant Status: Closed
This project determined the mode of inheritance for epilepsy in three breeds. For Vizslas, the researchers found that epilepsy is most likely an autosomal recessive trait (each parent must pass on one of the genes in order for puppies to be affected); for English Springer Spaniels, epilepsy is consistent with either simple autosomal recessive (carried on one gene) or polygenic recessive. For Beagles, it appears that epilepsy may be a sex-influenced recessive trait. In addition, the researchers began scanning the genome to look for linkages suggestive of epilepsy in all three breeds. This initial project has set the stage for identifying the epilepsy genes in those breeds. The groundwork accomplished allows a further, ongoing study to continue as the researchers work toward the goal of developing a genetic test so that breeders can make breeding decisions to eliminate the disease. The work done in these three breeds should provide assistance for researchers working on epilepsy in other breeds as well.
Patterson, E. E., Armstrong, P. J., O’Brien, D. P., Roberts, M. C., Johnson, G. S., & Mickelson, J. R. (2005). Clinical description and mode of inheritance of idiopathic epilepsy in English Springer Spaniels. Journal of the American Veterinary Medical Association, 226(1), 54–58. https://doi.org/10.2460/javma.2005.226.54
Patterson, E. E., Mickelson, J. R., Da, Y., Roberts, M. C., McVey, A. S., O’Brien, D. P., … Armstrong, P. J. (2003). Clinical Characteristics and Inheritance of Idiopathic Epilepsy in Vizslas. Journal of Veterinary Internal Medicine, 17, 319–325.
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