0001657T: Identification and Inheritance of DNA Markers for Addison's Disease

Grant Status: Closed

Grant Amount: $21,500
Dr. Anita M. Oberbauer, PhD, University of California, Davis
April 17, 2000 - April 16, 2001
Sponsor(s): Bearded Collie Club of America, Poodle Club of America Foundation
Breed(s): Toy Poodle, Bearded Collie, Miniature Poodle, Standard Poodle
Research Program Area: Endocrinology

Project Summary

The study found that Addison�s Disease (AD), the late-onset failure of adrenal gland function, is clearly inherited and appears to be regulated by a single gene that is inherited as an autosomal recessive. Researchers collected DNA samples and pedigrees from 390 Bearded Collies, 533 Standard Poodles and 167 Leonbergers. The samples were from both affected and non-affected dogs. Not enough affected Leonbergers were found, so research could not be completed for this breed. Researchers found that AD equally affects males and females; contrary to the bias in the literature, which stated that females were primarily affected. They also found that the coat color of the dog was not relevant. This study has provided the basis for an important next step: scientists will start screening DNA for a genetic marker. Once that marker is found, a DNA test to determine carriers for the disease can be developed.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $40
  • $60
  • $100
  • $250
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2015 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software