1456: Immunohistochemical and Mutational Analysis of p53 in Archival Benign and Malignant Tumors of Flat-Coated Retrievers

Grant Status: Closed

Grant Amount: $18,426.25
Dr. Guillermo C. Couto, DVM, Ohio State University
May 7, 1997 - May 6, 1998
Sponsor(s): Flat-Coated Retriever Foundation
Breed(s): Flat-Coated Retriever
Research Program Area: Treatment

Project Summary

Malignant histiocytosis, a form of cancer, is very common in Flat-Coated Retrievers (FCRs), but rare in most other breeds. The cancer appears to be clustered in different families or bloodlines. This project sought to identify whether a mutation in the p53 tumor-suppressor gene is responsible for the predisposition to this cancer. The scientists selected this gene because its mutation in humans has been shown to lead to a familial cancer. The researchers screened the genetic material of 30 blood samples: 21 from affected FCRs and nine from unaffected family members. They did not find a mutation in the p53 gene, but could not rule out the possibility that the gene might still be responsible. However the high prevalence of cancer in the breed might be due to other genetic abnormalities.

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