1445: Evaluation of the Canine HNF1 and HNF2 Genes as Candidates for the Locus Causing Fanconi Syndrome in Basenjis

Grant Status: Closed

Grant Amount: $16,000
Dr. Gary S. Johnson, DVM PhD, University of Missouri, Columbia
May 19, 1997 - May 18, 1998
Sponsor(s): Basenji Club of America, Inc. & Basenji Health Endowment
Breed(s): Basenji
Research Program Area: Prevention

Project Summary

This study ruled out two candidate genes as the gene responsible for Fanconi Syndrome (FS) in Basenjis. FS, an inherited disease, is a major health concern for the breed. With this syndrome, the tubules in the kidney, for unknown reasons, fail to do their job of reabsorbing nutrients into the dog�s system. Undetected, it will shorten the dog�s life. The researchers selected two candidate genes, HNF1 and HNF2, to test to see whether either is responsible for FS in Basenjis. After sequencing the HNF1 gene, they determined that it is not responsible for FS. Repeated attempts to sequence the HNF2 gene proved unsuccessful and were terminated when it became know that mutations in human HNF2 cause diabetes, rather than Fanconi Syndrome.

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