1444: Linkage Analysis Between Canine ATP7B Gene Markers and Heritable Copper Toxicosis in Bedlington Terriers
Grant Status: Closed
Project SummaryCopper toxicosis is an autosomal recessive disease (affected dogs must receive a gene from each parent) in which there is an accumulation of copper in the dog�s body, resulting in severe liver disease. The Bedlington Terrier is one of the breeds most affected by this disease. Humans suffer from a similar heritable disease called Wilson�s disease, and scientists have identified the gene in humans (the ATP7B gene) whose mutation causes Wilson�s disease. Previous research at another institution had cast doubt on the idea that the same gene in dogs causes CT, but it had not been definitively ruled out. This project sought to determine whether the canine equivalent of this gene causes CT. While the research was not definitive, it eliminated from consideration the ATP7B gene as the site of the Bedlington Terrier mutation.
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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.