1428: Inheritance Patterns and Molecular Genetic Analysis of Doberman Pinschers and Boxer Dogs with Familial Dilated Cardiomyopathy

Grant Status: Closed

Grant Amount: $71,783
Dr. Kathryn M Meurs, DVM PhD, Ohio State University
December 31, 1997 - December 30, 2000
Sponsor(s): American Boxer Charitable Foundation, Great Dane Club of America
Breed(s): Doberman Pinscher, Boxer
Research Program Area: Prevention

Project Summary

This study found that ventricular arrhythmias in Boxers are inherited as an autosomal dominant trait. Researchers found that asymptomatic Boxers have frequent ventricular premature complexes (VPCs), a specific type of irregular heartbeat that is a common form of ventricular arrhythmia. They determined that a two- to three-minute electrocardiogram (ECG) is a poorly sensitive indicator of VCPs, and instead recommend the use of a 24-hour ambulatory ECG (Holter monitor), even on asymptomatic Boxers. In studying Doberman Pinschers, they ruled out some potential candidate genes for study by demonstrating that two specific proteins and a specific gene that are abnormal in some humans with dilated cardiomyopathy (DCM) a primary heart muscle disorder that can cause the heart to beat erratically are normal in Dobermans with DCM. Linkage analyses for both Boxers and Dobermans.

Publication(s)

- Meurs KM, Magnon AL, Spier AW, et al. Evaluation of the cardiac actin gene in Doberman Pinschers with dilated cardiomyopathy. American Journal of Veterinary Research 2001;62:33-36. - Meurs KM, Spier AW, Wright NA, et al. Comparison of in-hospital v

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