Advances in Diagnosis and Treatment of Canine IBD
Presentation by Albert Jergens, DVM, MS, PhD Professor of Veterinary Clinical Sciences at Iowa State University at the 2011 National Parent Club Canine Health Conference hosted by the AKC Canine Health Foundation.
Presentation Abstract: Canine inflammatory bowel disease (IBD) denotes a heterogeneous group of idiopathic, chronic, relapsing inflammatory disorders of the gastrointestinal tract that are immunologically-mediated. While their exact etiologies remain unknown, research results suggest that interplay between genetic factors and enteric bacteria are crucial for disease development, owing to abnormal host responses directed against the commensal microbiota. Key clinical signs include vomiting, diarrhea and weight loss, and histopathologic lesions of inflammation may involve the stomach, small intestine, or colon. Recent advances in molecular tools, disease activity indices, and biomarker development now permit objective assessment of IBD severity at diagnosis and in response to various therapies. Treatment of IBD involves both dietary and pharamacologic interventions as well as therapeutic manipulation of the enteric microbiota through the use of antibiotics, prebiotics, and probiotics. This presentation will highlight recent research advances in canine IBD and offer insight into future research directions.
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