Three-dimensional Echocardiographic Determinants of the Age of Onset of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels
The relevance of this project for CKCSs is represented by its potential for identifying tools to be used for screening and breeding programs. From the results of the breeding programs implemented so far, it can be noticed that using only cardiac auscultation to guide selective breeding in United Kingdom and Sweden had been somewhat disappointing. On the contrary, encouraging results were obtained by the Danish CKCSs breeding program, which used an association of echocardiography and cardiac auscultation as screening method. Therefore, the sensitivity of the method used for screening and defining breeding criteria is key for successfully lowering the prevalence of the disease. Currently, echocardiographic and echo Doppler techniques, can identify MMVD only after it has progressed to cause alterations to the MV structure and an altered leaflet’s coaptation.
Purebred Cavalier King Charles Spaniels who are >18 months of age
No history of heart disease
Mild murmurs (2/6 or less) are acceptable
Owners Responsibilities (Samples and Information to be collected):
Standard 2D and 3D echocardiography
Rechecks every 4 months
Dogs will undergo standard echocardiographic and physical examination to establish baseline measurements. Dogs will return for recheck examinations every 4 months until mitral valve disease develops or until the end of the study period (April 2022).More Information
Name: Michele Borgarelli
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.