Lymphoma Research
The AKC Canine Health Foundation (CHF) supports critical research into understanding canine lymphoma.
Why We Focus on Lymphoma
Canine lymphoma is a type of cancer that affects a dog’s lymphatic system, which is part of the immune system. Lymphoma is now understood to encompass more than 30 different types of cancer affecting immune system cells, and it can affect various organs, including lymph nodes, spleen, liver, and bone marrow. While some forms of this disease are slow-growing or very responsive to treatment, other forms are aggressive and rapidly impact health. As our understanding of lymphoma grows, more accurate diagnostics and novel treatment strategies are needed to provide personalized and more effective management strategies for affected dogs.
Research Grants
Lymphoma ● $167,442
03300: Probiotic Prevention of GI Hyperpermeability and Metabolome Disturbances in Dogs with Multicentric Lymphoma Undergoing Multi-drug Chemotherapy
Breed(s): All Dogs
Researcher(s): Maria C Jugan, DVM, MS, DACVIM
Sponsor(s): Affenpinscher Rescue of America, Portuguese Water Dog Foundation
Lymphoma ● $94,987
03294: Formulation of Radiopharmaceutical Cocktails with MIRDcell AI to Treat B Cell Lymphoma in Dogs
Breed(s): All Dogs
Researcher(s): Nora L Springer, DVM, PhD, DACVP and Roger Howell, PhD
Sponsor(s): Basset Hound Club of America Foundation, Inc., Bull Terrier Club of America
Lymphoma ● $42,263
03257: B cell Subset Analysis Through Spatial Transcriptomics with Application to B cell Disorders
Breed(s): Bulldog
Researcher(s): Emily D Rout, DVM, PhD
Sponsor(s): Spinone Club of America, Tibetan Terrier Club of America/Tibetan Terrier Health & Welfare Foundation
Lymphoma ● $174,960
03194: A Blueprint to Develop Next-Generation CAR T Therapy for Canine Lymphoma
Breed(s): All Dogs
Researcher(s): Matthew J Atherton, BVSc, PhD
Sponsor(s): Berner Lovers, Collie Health Foundation, Golden Retriever Foundation, Irish Setter Club of America Foundation, Jeffrey Pepper, Portuguese Water Dog Foundation, Rottweiler Health Foundation, Starlight Fund
Lymphoma ● $84,753
03144: Lomustine, Asparaginase, Procarbazine and Prednisone (LAPP) for Canine Multicentric Lymphoma: A Practical Multiagent Chemotherapy Protocol that Avoids Injectable Cytotoxics
Breed(s): All Dogs
Researcher(s): Douglas H Thamm, VMD
Sponsor(s): American Wirehaired Pointing Griffon Association / Foundation, Flat-Coated Retriever Foundation, Irish Wolfhound Club of America, Inc., Irish Wolfhound Foundation, Golden Retriever Foundation
Lymphoma ● $14,904
03102-A: Can Deep Learning (CNN) Detect Minimal Residual Disease (MRD) in Dogs Treated for Lymphoma?
Breed(s): All Dogs
Researcher(s): Kurt Zimmerman, DVM PhD
Sponsor(s): Chasing A Cure, Flat-Coated Retriever Foundation
Lymphoma ● $89,484
03007: Chimeric BiTE-redirected Anti-viral T Cells for Fratricide of Minimal Residual Disease in T-cell Malignancies
Breed(s): All Dogs
Researcher(s): Paul Hess, DVM, PhD
Sponsor(s): American Black & Tan Coonhound Club, Golden Retriever Foundation
Lymphoma ● $58,136
02998: Whole-Exome and Transcriptome Sequencing of Canine Small Cell B Cell Lymphoma and Comparative Analysis to Diffuse Large B Cell Lymphoma
Breed(s): All Dogs
Researcher(s): Anne Avery, DVM, PhD
Sponsor(s): Collie Health Foundation, Golden Retriever Foundation
Lymphoma ● $149,979
02912: Adoptive Natural Killer (NK) Cell Immunotherapy for Canine Lymphoma
Breed(s): All Dogs
Researcher(s): William Kisseberth, DVM, PhD
Sponsor(s): Australian Shepherd Health & Genetics Institute, Chasing A Cure, Irish Wolfhound Foundation, Golden Retriever Foundation, Gordon Setter Club of America, Inc., National Beagle Club, Pembroke Welsh Corgi Club of America, United States Australian Shepherd Foundation, Westie Foundation of America, Inc., Whippet Health Foundation
Lymphoma ● $108,751
02885: Exposure to Environmental Chemicals in Boxers with Lymphoma
Breed(s): Boxer
Researcher(s): Lauren Trepanier, DVM, PhD
Sponsor(s): Compton, Bob and Bobbi, University of Wisconsin, Madison
Lymphoma ● $33,234
02890: Characterizing the LINE-1 Transcriptome in Canine High-grade Peripheral T-cell Lymphoma by RNAseq to Gain Insight into Mechanisms of Drug and Immune Resistance
Breed(s): All Dogs
Researcher(s): Paul Hess, DVM, PhD
Sponsor(s): Australian Shepherd Health & Genetics Institute, Golden Retriever Foundation, Jeffrey Pepper, Westie Foundation of America, Inc.
Lymphoma ● $75,600
02772: Identifying Early Stage Ultra-rare Mutations as Predictive Biomarkers of Lymphoma in High-risk versus Low-risk Breeds Within the Dog Aging Project
Breed(s): Boxer, Chow Chow, Dalmatian, Greyhound, Labrador Retriever, Rottweiler
Researcher(s): Daniel Promislow, PhD
Sponsor(s): American Bouvier des Flandres Club – Bouvier Health Foundation, Flat-Coated Retriever Foundation, Akita Club of America, Inc., Collie Health Foundation, Portuguese Water Dog Foundation, Pug Dog Club of America, Inc.
Lymphoma ● $14,580
02751-A: Luteinizing Hormone Receptor Activation Induces Migration and Adhesion in Neoplastic Canine Lymphocytes
Breed(s): All Dogs
Researcher(s): Michelle Kutzler, DVM, PhD
Sponsor(s): Australian Shepherd Health & Genetics Institute, Golden Retriever Foundation, Labrador Retriever Club, Inc., Portuguese Water Dog Foundation
Lymphoma ● $14,996
02739-A: The Role of the Putative Tumor Suppressor Gene SETD2 in Canine Diffuse Large B-cell Lymphoma
Breed(s): All Dogs
Researcher(s): Bonnie Harrington, DVM, PhD
Sponsor(s): Australian Shepherd Health & Genetics Institute, Affenpinscher Rescue of America, Collie Health Foundation, Irish Setter Club of America Foundation
Lymphoma ● $78,069
02309-T: Targeting the Cancer Epigenome: The Effect of Specific Histone Lysine Methyltransferase Inhibition in Canine B-Cell Lymphoma
Breed(s): All Dogs
Researcher(s): Angela McCleary-Wheeler, DVM, PhD
Sponsor(s): American Pointer Club, Australian Shepherd Health & Genetics Institute, Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America, Irish Setter Club of Milwaukee, Inc., American Boxer Charitable Foundation, Bull Terrier Club of America, Collie Health Foundation, Gordon Setter Club of America, Inc., Newfoundland Club of America Charitable Trust, Portuguese Water Dog Foundation, United States Australian Shepherd Foundation, Westie Foundation of America, Inc.
Join Us in Advancing
Canine Health
With more than $1.1 million supporting canine lymphoma research, CHF is deeply committed to improving the lives of affected dogs and their families.
