01684-A: Improved Method for Early Diagnosis of Atypical Cushing’s Disease
Twenty-eight dogs were enrolled in the study to compare cortisol concentrations among healthy dogs, dogs with excess cortisol associated with pituitary dependent Cushing’s syndrome and dogs categorized as having “atypical” Cushing’s syndrome. The latter is diagnosed when dogs have clinical signs suggestive of excess cortisol (drinking a lot, infections, losing hair) but increases in peak […]
02342-A: Molecular Analysis of Giant Schnauzer-Type Congenital Hypothyroidism
Isolated congenital hypothyroidism (CH) is a condition occurring at or near birth characterized by insufficient thyroid hormone production. The disorder in purebred dogs is usually inherited and leads to dwarfism and mental dullness. CH in Giant Schnauzers (GS) was first described in 1991 (Greco, et al) as a likely autosomal recessive disorder due to failed […]
00877-A: Collecting a Second Cohort of Hypothyroid Dogs
Hypothyroidism represents a significant clinical problem in dogs, but definitive diagnosis remains difficult. Canine hypothyroidism is considered to be an autoimmune disease, based on its clinical and histological similarities to Hashimoto’s thyroiditis in man (Beierwaltes and Nishiyama 1968), and because of the presence of autoantibodies to thyroglobulin (Mizejewski et al. 1971). Immune-mediated conditions are likely […]
0001450: Thyrotropin for Assessment of Thyroid Function
Hypothyroidism (low thyroid function) is the most common endocrine disorder in dogs. It can be effectively treated with synthetic thyroid replacement once it is diagnosed. But accurate diagnosis of hypothyroidism is difficult with the current blood tests available. This project sought to develop an improved blood test for canine hypothyroidism by accurately measuring a hormone […]
00372: Determination of Breed-Specific Reference Ranges for Assessing Thyroid Function in Several Breeds
All dogs have completed the recruitment, enrollment and screening process. All samples from all dogs have been collected. Six hundred dogs were enrolled and 77 dogs were rejected due to their failure to pass inclusion criteria. All analytical testing (health screening data and hormone analyses) has been completed. Preliminary data has been presented at the […]
00876-A: Performing a whole genome screen on Rhodesian Ridgebacks with thyroglobulin antibody positive hypothyroid disease
We have previously identified a set of genes associated with hypothyroid disease in a region of the genome that is rich in immune genes. We have now performed a whole genome scan comparing 58 Rhodesian Ridgebacks, Doberman and Boxers having hypothyroid disease with 100 unaffected control dogs, which has revealed 210 SNPs that are significantly […]
02138: Development of Accurate Diagnostic Tests for Canine Hypothyroidism
Primary hypothyroidism is one of the most common endocrine disorders in dogs. The insufficient secretion of thyroid hormones may result in severe physical and mental changes, such as lethargy, alopecia, obesity, decreased cardiac output, and decreased renal perfusion. The diagnosis of hypothyroidism is sometimes problematic. The circulating thyroxin (T4) concentration is below the reference range […]
02298-MOU: Using OFA Testing to Assess Progression of Canine Autoimmune Thyroiditis
Hypothyroidism may be the most common endocrine disorder in adult dogs. As is best currently understood, a majority of cases are caused by autoimmune thyroiditis (AIT), a disorder in which the body’s own immune system attacks the thyroid gland. This causes progressive, irreversible destruction of thyroid gland cells resulting in loss of thyroid hormone production. […]
02875: Canine Pituitary Adenoma Organoids (CaPitO) as an in vitro Model for Canine Cushing’s Disease
Pituitary-dependent hypercortisolism (PDH) caused by a pituitary tumor (adenoma) is one of the most common endocrine disorders in dogs. Medical treatment options that focus on the pituitary tumor are currently lacking. In this project, investigators aim to validate three-dimensional Canine Pituitary adenoma Organoids (CaPitOs) as a model for canine PDH, and use this to find […]
02659: Breed Specific Reference Ranges for Canine Thyroid Testing
Thyroid disease is common in dogs with the incidence of hypothyroidism approaching 30% in some breeds. Evaluation of thyroid function currently involves comparison of thyroid hormone concentrations in an individual patient with reference ranges generated from past testing of dogs of many breeds. However, while such all-breed reference ranges are generally accurate, they may not […]