0002434: Recombinant Thyrotropin (TSH): Standard for the Next Generation of Canine TSH Immunoassays with Improved Sensitivity
Overall, this research project completed the genetic phase of the project and are reproducibly producing reasonable quantities of recombinant canine TSH in vitro and purifying it with high recovery to high purity. In the future, this standard can serve as a reproducible standard for all available canine TSH assays. Although the researchers did not succeed […]
00844-A: Effect of Phytoestrogens Enterolactone and Enterodiol on Steroidogenesis in Adrenal Cells: Investigating a Potential Therapy for Canine Hyperestrinism
The University of Tennessee Clinical Endocrinology Service is a recognized center of excellence in adrenocortical disease in dogs and receives diagnostic samples from all 50 states and several foreign countries. It has been observed that approximately 10 percent of dogs suspected of having adrenal disease only have elevated estrogen concentrations; this is known as hyperestrinism. […]
0002273: Preclinical Detection of Hypoadrenocorticism (Addison’s Disease) in Dogs: Development and Evaluation of Laboratory Techniques for the Diagnosis of Immune-Mediated Canine Adrenal Disease
Addison’s disease in the dog has been well studied. It is very similar to the disease in humans. Signs include anorexia, vomiting, weakness, pain, diarrhea, lethargy, the inability to handle stress, and, in severe cases, cardiac arrest. Since there is no early diagnostic test available and clinical signs are nonspecific, more than one-third of affected […]
01674-A: Molecular Basis of Congenital Hypothyroidism with Goiter in Spanish Water Dogs
Recently, congenital hypothyroidism with goiter (CHG) occurred in Spanish Water Dogs (SWD), a breed that was recognized by the AKC Foundation Stock Service in 2005 and approved for a variety of performance competitions in 2008. Hormones produced by the thyroid gland are crucially important for the health and development of dogs. Affected puppies exhibited mental […]
02011: Identification of Novel Drugs to Halt the Metastasis of Tumors That Cause Cushing’s Syndrome
Tumors of the adrenal gland that lead to Cushing’s syndrome are characterized by excessive cortisol secretion which in turn causes these tumors to be aggressive and rapidly metastasize. Recently, a critical role of steroidogenic factor (SF-1) in adrenal tumor formation has been demonstrated. Elevated SF-1 levels trigger tumor formation in mice and are associated with […]
02850-A: Potential Reduction of Systemic and Pancreatic Inflammation using Fenofibrate in Diabetic Dogs
Diabetes mellitus (DM) is a common disease in dogs and a cause of significant patient morbidity as well as emotional and financial stress to pet owners. In this study, investigators will examine the effect of fenofibrate on alleviating some of the complications of DM. Fenofibrate is a drug known to decrease blood lipid levels that […]
00594: Effect of Melatonin on Adrenal Steroids in Dogs with Aberrant Adrenocortical Disease
Aberrant adrenocortical disease (ACD) is a frequently found variant of Cushings syndrome in dogs. ACD is a disease in which cortisol usually remains at normal concentrations (which is misleading), but excessive adrenal intermediate steroids are secreted causing clinical signs of canine Cushings syndrome. The Clinical Endocrinology Service at the University of Tennessee is an internationally […]
02488: Addison’s Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders
Hypoadrenocorticism or Addison’s disease (AD) is a life-threatening condition that afflicts multiple dog breeds and results from autoimmune destruction of the adrenal glands. Similarly, another canine autoimmune condition that causes pain and suffering is Symmetrical Lupoid Onychodystrophy (SLO). Both AD and SLO are postulated to be complexly inherited and preliminary data suggest a common set […]
0001657T: Identification and Inheritance of DNA Markers for Addison’s Disease
A study confirmed that Addison’s Disease (AD) in dogs is an inherited autosomal recessive trait, affecting both sexes equally, and lays the groundwork for a DNA test to identify carriers.
00305: Histocompatibility Alleles Conferring Susceptibility to Canine Diabetes, Immune-Mediated Thyroiditis and Immune-Mediated Hemolytic Anemia
Autoimmune diseases cause significant amounts of mortality and debilitating disease in dogs. In humans many autoimmune diseases occur only in individuals expressing one of the few predisposing histocompatibility genes. For example, all cases of type I diabetes in humans are associated with only a few of the many alleleic forms of class II histocompatibility genes. […]