00615A-T: Heritable and Sporadic Genetic Lesions in Canine Lymphoma
We are aware that these progress reports are made available to representatives from breed clubs or agencies that have contributed financially to support the project. We respectfully remind readers that data included in this progress report may be preliminary and require further confirmation. We request that all contents of this report be maintained in strict […]
02912: Adoptive Natural Killer (NK) Cell Immunotherapy for Canine Lymphoma
Natural killer (NK) cells are immune cells whose function are to eliminate virus infected and cancer cells from the body. In this clinical trial investigators will test the feasibility, safety and immunologic and biologic activity of adoptive NK cell therapy combined with chemotherapy to treat dogs with lymphoma. NK cells from healthy dogs) will be […]
01494-A: Identifying the cause of drug resistance in canine lymphoma
This study was being conducted at the Louisiana State University School of Veterinary Medicine. Unfortunately we were only able to enroll 9 cases to date. Additionally, many of the dogs enrolled have not progressed with their cancer in a normal fashion. However, after analysis of the data to date, we have found that the levels […]
02751-A: Luteinizing Hormone Receptor Activation Induces Migration and Adhesion in Neoplastic Canine Lymphocytes
Luteinizing hormone (LH) is secreted from the brain (pituitary) in sexually intact dogs to stimulate synthesis of estrogen and testosterone in females and males, respectively. However, LH is secreted at concentrations up to 20 times higher following gonad removal with spaying or castration because hormonal negative feedback is lost. Although LH is considered to be […]
03144: Lomustine, Asparaginase, Procarbazine and Prednisone (LAPP) for Canine Multicentric Lymphoma: A Practical Multiagent Chemotherapy Protocol that Avoids Injectable Cytotoxics
Lymphoma is one of the most common malignancies in dogs. Injectable multi-drug chemotherapy remains the standard of care, and is associated with high response rates and meaningful prolongation of life. However, a minority of dogs with lymphoma are treated with injectable chemotherapy, in part due to an inability of non-specialty practices to safely handle injectable […]
01918-G: Discovery of Biomarkers to Detect Lymphoma Risk, Classify For Treatment, and Predict Outcome in Golden Retrievers
Lymphoma strikes 1 in 8 Golden Retrievers, approximately one-third of the cases being B-cell. While T-cell classifications currently inform therapy choices for dogs, B-cell classifications have been investigated little in Golden Retrievers. Dr. Jeffrey Bryan, in collaboration with Drs. Anne Avery and Heather Wilson will focus their efforts on an area of emerging importance in […]
03257: B cell Subset Analysis Through Spatial Transcriptomics with Application to B cell Disorders
The purpose of this study is to identify different types of normal B cells in the canine immune system and therefore improve the ability to study B cell diseases in dogs. One aim of this study is to sequence different populations of B cells based on their location in the lymph node and spleen. The […]
00809-A: Rel Transformation of Canine Lymphoid Cells: Towards the Development of Relevant Canine Lymphoma Cell Lines
In this study we aim to use retroviral Rel expression plasmids to infect lymphocytes isolated from normal dogs and neoplastic lymphoblasts isolated from dogs with high-grade B cell lymphoma and document appropriate Rel and/or Bcl-2 protein expression. These experiments will provide proof of principle that Rel expression plasmids can infect and replicate in canine lymphoid […]
01113: Canine Non-Hodgkin Lymphoma: Characterization and Prognostic Value of Cancer Stem Cells
Stem cells are cells which, in general, have the ability to give rise to multiple different (differentiated) cell types while at the same time maintaining their own population of undifferentiated stem cells. Embryonic stem cells are the quintessential stem cell and have the ability to form any tissue of the embryo, fetus, and adult. However, […]
01344-A: Comparison of percentage of T regulatory cells in dogs with spontaneously occurring lymphoma following oral versus intravenous cyclophosphamide
Lymphoma, a cancer of the lymph nodes, is among the most common cancers seen in dogs. Although highly responsive to chemotherapy, almost all dogs ultimately relapse and die of this disease. A subset of immune cells called T regulatory cells (Tregs) determines what cells belong in your body. Tregs can prevent other immune cells from […]